ID: CfA262643
Primary Contact:
Haideh Hirmand, Haideh Hirmand, MD, PC New York, United States haidehhirmandmd@drhirmand.com
All Authors:
Haideh Hirmand, Haideh Hirmand, MD, PC (Primary Presenter)
Johnny Franco
Drew Taylor, ACORN Biolabs
Lisa Campbell, ACORN Biolabs
Heather Dwyer, ACORN Biolabs
Nicola Lowrey, N2 Aesthetics
Christie Prendergast
Julia Carroll, Compass Dermatology
Sonya Cook, Compass Dermatology
Shawn Seit, Rejuuv Medispa
Amber Bocknek, Amber Bocknek, MD
Jean Carruthers, Carruthers Cosmedic
Abstract Book:
Yes - I give my consent
Al Disclosure Statement:
No, Al was not used
Presentation Type:
State-of-the-Art Lecture;Hot Topic
Title:
Autologous Hair Follicle Derived Secretome as Adjunct to Aesthetic Procedures
Abstract Type:
General Submission
Submission Category:
Minimally Invasive (Including Regenerative Medicine)
Abstract:
Introduction
Regenerative medicine, as a new approach to facial rejuvenation, holds promise as a safe, effective, and durable strategy to reverse visible skin aging. Among regenerative treatments used in the aesthetics field, such as exosomes and platelet rich plasma, there are cell derived secretomes, which contain the complete set of all molecules secreted by a cell, tissue, or organism into its environment. The purpose of this observational study is to evaluate real-world clinical and patient reported outcomes measuring the effectiveness and safety of a topical autologous hair follicle derived secretome as an adjunct to aesthetic procedures.
Materials and Methods
Subjects receiving facial microneedling followed immediately by application of an autologous hair follicle-derived secretome were enrolled. Autologous secretome was created by plucking 50-70 of the subject's hair follicles, ten of which were cultured for 4 weeks in a proprietary media that was free of animal and human components, while the remaining follicle stem cells were cryopreserved for future use. Media containing the secretome (conditioned media) was collected from the 10 follicles each week for 4 weeks. Subjects purchased 12 vials of secretome and paid for their medical aesthetic procedure. Subject reported post-procedure symptom scores (0-best possible to 10-worst imaginable) and downtime from days 1-7, impressions of the product on day 14 and satisfaction, skin improvement and global aesthetic improvement on days 30, 60, 90, 180 and 365 days were collected. Investigators reported global aesthetic improvement and scientific assessment scale of skin quality on days 30, 60, 90, 180 and 365 days.
Results
Subjects (N=59) received microneedling treatments with secretome and were followed up to 365 days. Within 4 days of follow-up 100% of subjects reported ending downtime, and all post-procedure symptom scores were below 1 point. One hundred percent of subjects reported improvement and were satisfied by 365 days. Subjects reported improvement in wrinkles (60%), less sagging (80%), glowing more (100%), smoother texture (60%), and more even skin tone (100%) at 180 days. Physician global aesthetic improvement scores reported 100% of subjects improved at days 60, 90, 180 and 365 days. SASSO results
showed significant (p<0.5) improvement in wrinkles, loss of elasticity, skin roughness, pigmentation and pore size by 60 days. No treatment-related AEs were reported.
Discussion
Subject outcomes demonstrate short downtimes, low post-procedure symptom scoring, and 100% improvement and subject satisfaction. Investigator rated improvement supported subject reported outcomes of improvement. Downtime was shorter compared to reports in the literature for microneedling alone and patients were more satisfied with their improvement. This real-world observational study of an autologous hair follicle derived secretome shows promise for a new regenerative treatment approach. Further analysis of the final comprehensive data set will provide additional insights into the optimal use of this autologous hair follicle-derived secretome in the clinic and at home.