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The Truth About Fillers


We are nothing if not evidence based in our approach. Here we quote from the National Library of Medicine.

Neocollagenesis and Neoelastinogenesis: From the laboratory to the clinic.
Journal of Cutaneous Aesthetic Surgery. 2016.  July-September
HA fillers were designed to provide temporary correction to enhance static contour defects. It is now theorised that these HA fillers may have more permanent and longer lasting effects.[30] Wang et al. explored the mechanisms behind potential neocollagenesis from injection of cross-linked HA fillers.[31] They were able to prove that fibroblasts take on a more morphologically stretched shape and a more active phenotype as a result of HA fillers. HA injection, however, was not shown to have a direct stimulatory effect on fibroblasts. Instead, it was demonstrated and theorised that existing collagen fibers are stretched by HA injection, which imposes mechanical tension on surrounding fibroblasts, therefore, stimulating them to increase production of Types 1 and 3 collagen. Procollagen, MMP and MMP tissue inhibitors of metalloproteinase (TIMP-1) were also measured by ELISA and quantitative PCR. They also found a statistically significant increase in procollagen, TIMP-1 and gene expression of procollagen 1 and 3, 1 month after injection. Procollagen levels remained elevated at three and 6 months of subsequent injections

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